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  • Title: Chronic neutropenia: possible association with Sjögren's syndrome.
    Author: Starkebaum G, Dancey JT, Arend WP.
    Journal: J Rheumatol; 1981; 8(4):679-84. PubMed ID: 7299770.
    Abstract:
    Three white males, ages 42-59, with chronic neutropenia are described. All 3 patients had splenomegaly, positive tests for rheumatoid factor, elevated erythrocyte sedimentation rates, hypergammaglobulinemia and bone marrow examinations which showed normal to increased cellularity. Two of the 3 patients had recurring arthralgias and positive tests for antinuclear antibodies. All 3 patients had evidence for decreased tearing suggestive of Sjogren's syndrome, but in only 1 patient was a positive lip biopsy obtained. One patient had repeated cutaneous infections which ceased after splenectomy resulted in an increased neutrophil count. Serum IgG neutrophil-binding and in vivo neutrophil kinetic studies on 1 patient were consistent with a humoral immune mechanism for his neutropenia.
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