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  • Title: Cerebrospinal fluid penicillin levels during therapy for latent syphilis.
    Author: Ducas J, Robson HG.
    Journal: JAMA; 1981 Dec 04; 246(22):2583-4. PubMed ID: 7299984.
    Abstract:
    Cerebrospinal fluid and serum penicillin levels were determined in patients with latent syphilis. Mean serum concentration one week after the third weekly dose of 2.4 million units penicillin G benzathine was 0.32 units/mL. Concurrent administration of probenecid orally produced a mean serum penicillin level of 0.41 units/mL. Doubled penicillin doses without and with daily orally administered probenecid resulted in mean serum concentrations of 0.75 and 1.00 units/mL, respectively. Two of six patients in the last group had CSF penicillin concentrations greater than 0.03 units/mL.
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