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  • Title: [2 cases of malformations of a limb in infants of mothers treated with an antiemetic in a very early phase of pregnancy].
    Author: Soverchia G, Perri PF.
    Journal: Pediatr Med Chir; 1981; 3(1):97-9. PubMed ID: 7301625.
    Abstract:
    Two cases of fetal malformation of a limb are described. The mothers of our patients took an antiemetic, Debendox (dicyclomine hydrochloride 10 mg, doxylamine succinate 10 mg, pyridoxine hydrochloride 10 mg), in early pregnancy, five-six weeks after the last menstrual period. The drug was administered during limbs-buds development period which is thought to occur at 43-46 days after conception. The fetal malformation described, are confronted with congenital abnormalities reported by other authors who suspect that, in early pregnancy, Debendox may have teratogenic properties. Nevertheless, prospective studies of gravidas and their offspring have found no evidence to suggest that Debendox is teratogenic in humans.
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