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  • Title: [Interaction between benzene and toluene in long term inhalation exposure in rats (author's transl)].
    Author: Gradiski D, Bonnet P, Duprat P, Zissu D, Magadur JL, Guenier JP.
    Journal: Toxicol Eur Res; 1981 Jul; 3(4):201-6. PubMed ID: 7302947.
    Abstract:
    Industrial chemicals are seldom used as pure substances; hazards resulting from exposure to mixtures have, however not been solved. Our study deals with chronic inhalation toxicity of a mixture of benzene and toluene; few studies have been completed on this subject. Our results show: - leucopenia with benzene alone, at a concentration of 50 p.p.m., that is not detectable in the presence of toluene; - metabolic variations consisting in: a decrease in the phenol urinary rate versus time with benzene alone; a sharp decrease of this rate from the third month of exposure on, in presence of toluene.
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