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  • Title: Inhibition of rat platelet 5-hydroxytryptamine uptake by chlordimeform.
    Author: Johnson TL, Knowles CO.
    Journal: Toxicol Lett; 1981 Sep; 9(1):1-4. PubMed ID: 7302966.
    Abstract:
    Chlordimeform, a formamidine insecticide and acaricide, and two of its toxic N-demethyl metabolites inhibited rat blood platelet 5-hydroxytryptamine (5-HT) uptake. A direct relationship existed between formamidine uptake inhibitory potency and N-demethylation. Didemethylchlordimeform, the most potent formamidine inhibitor of 5-HT uptake examined, had a pI50 of 4.2. However, it was appreciably less active than the classical inhibitor imipramine, which yielded 86.4% inhibition of 5-HT uptake at a concentration of 1.10(-5) M.
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