These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Potentiating effects of 5-hydroxytryptamine and histamine on nerve stimulation-induced contractions of the rabbit mesenteric artery.
    Author: Moritoki H, Su C.
    Journal: Arch Int Pharmacodyn Ther; 1981 Aug; 252(2):186-95. PubMed ID: 7305557.
    Abstract:
    Contractions of the rabbit mesenteric artery induced by transmural adrenergic nerve stimulation at a frequency of 8 Hz were augmented by 5-hydroxytryptamine (5-HT), quipazine, methysergide, tolazoline, histamine, angiotensin II and 4-aminopyridine. The potentiating effect of 5-HT was partly reduced by cyproheptadine and by prolonged treatment with methysergide. After treatment with a histamine H1-antagonist, chlorpheniramine, histamine failed to augment but contrarily inhibited the response. This inhibition was reversed after subsequent administration of an H2-antagonist, metiamide. These results indicate that H1- and H2-receptors mediate the potentiation and inhibition, respectively, and that the effect medicated by H1-receptors normally predominates. It seems unlikely that the potentiation by these agents is due to prevention of norepinephrine metabolism, augmentation of norepinephrine release or prostaglandin formation. It is suggested that 5-HT and histamine act on postjunctional 5-HT and histamine receptors, respectively, to modulate the transmitter effect and that norepinephrine, methysergide and tolazoline may also act through the 5-HT receptors.
    [Abstract] [Full Text] [Related] [New Search]