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  • Title: [Granulocytic function in children with selective IGA deficiency and recurrent infections: demonstration of altered chemotaxis].
    Author: De Martino M, Vierucci A, Redi Orienti M, Novembre E.
    Journal: Boll Ist Sieroter Milan; 1981 May; 60(2):155-62. PubMed ID: 7306391.
    Abstract:
    Some parameters of neutrophil function (NBT reduction, bactericidal activity, chemotaxis) have been examined in 15 children with selective IgA deficiency and recurrent infections of respiratory and/or intestinal tract. In no case a defect in NBT reduction was observed. Mean results of bactericidal activity were normal, but in one child bacterial killing was lower than 2 SD of normal values. In 7 out 12 of patients a severe defect in cellular chemotaxis was proved, and in 1 a poor chemotactic activity of the serum was observed. Correlations between the defect in neutrophil chemotaxis and selective IgA deficiency are discussed.
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