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  • Title: Effects of chronic haloperidol and sulpiride treatment on rat nigral GABA content.
    Author: Rampello L, Giammona G, Patti F, Reggio A, Nicoletti F, Di Giorgio RM, Condorelli DF.
    Journal: Boll Soc Ital Biol Sper; 1981 Aug 15; 57(15):1608-11. PubMed ID: 7306401.
    Abstract:
    The effects of chronic haloperidol and sulpiride treatment on nigral GABA content were investigated in rats. Chronic sulpiride treatment is capable of inducing an increase in nigral GABA content whilst no significant effect is observed following chronic haloperidol treatment at the doses used. The different effects of haloperidol and sulpiride on nigral GABA content were related to the different neuropharmacological spectrum of the two drugs.
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