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  • Title: Non-suppressible insulin-like activity during pregnancy in women with diabetes mellitus.
    Author: Herington AC, Martin FI, McBain JC.
    Journal: Clin Endocrinol (Oxf); 1981 Aug; 15(2):133-7. PubMed ID: 7307287.
    Abstract:
    Serum levels of the growth factor non-suppressible insulin-like activity (NSILA-S) have been measured in eleven pregnant women with diabetes mellitus during pregnancy and immediately (2 days) after birth. A significant increase in mean levels was observed with increasing gestation, reaching a peak at the time of delivery and subsequently returning to non-pregnant levels within 2 days. The NSILA-S levels in diabetic pregnancies were not different from those in non-diabetic pregnancies and there were no significant correlations between NSILA-S and birth weight, maternal diabetic control, age or duration of diabetes or the treatment required. The physiological role of high NSILA-S levels during pregnancy still requires elucidation.
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