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  • Title: [Heteroarylalkanoic acids with potential anti-inflammatory activity. II].
    Author: Andrisano MG, Di Bella M, Ferrari P, Raffa L, Baggio GG.
    Journal: Farmaco Sci; 1981 Nov; 36(11):905-15. PubMed ID: 7308458.
    Abstract:
    A series of (1,2,4-benzothiadiazin-1,1-dioxide-3-yl)acetic acids was prepared so that antiinflammatory activity could be tested. Some of the compounds synthetized showed marked activity against plantar edema induced by carrageenin and/or dextran. It was found that in this series antiinflammatory activity is related to the nature of the substituents on the benzene ring as well as their number, dihalogen substitution being the most favourable modification and dichlorosubstitution in particular giving the compounds most active against both types of edema.
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