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  • Title: Calcium-induced calcium release from sarcoplasmic reticulum vesicles.
    Author: Nagasaki K, Kasai M.
    Journal: J Biochem; 1981 Sep; 90(3):749-55. PubMed ID: 7309698.
    Abstract:
    Passive permeability of sarcoplasmic reticulum vesicles for Ca2+ was studied by the Millipore filtration method using 45Ca. The efflux rate of Ca2+ increased in the presence of micromolar concentrations of Ca2+ in the medium when the Mg2+ concentration was low. The dependence of the Ca2+ release rate on the extravesicular Ca2+ concentration was not affected by the intravesicular Ca2+ concentration. The Ca2+ release was enhanced by caffeine, but reduced by procaine and Mg2+. These properties suggest that the Ca2+ release is a similar phenomenon to the Ca2+-induced Ca2+ release observed in skinned muscle fiber. Kinetic analysis of the efflux curves suggests that two types of vesicles exist in our preparation; about 2/3 of the vesicles release Ca2+ as described above and the remainder does not.
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