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  • Title: Studies on the structures of the carbohydrate moiety of human prothrombin.
    Author: Mizuochi T, Fujii J, Kisiel W, Kobata A.
    Journal: J Biochem; 1981 Oct; 90(4):1023-31. PubMed ID: 7309709.
    Abstract:
    Human prothrombin contains three asparagine-linked sugar chains in one molecule. The sugar chains were quantitatively liberated as radioactive oligosaccharides from the polypeptide moiety by hydrazinolysis followed by N-acetylation and Nab3H4 reduction. All of the oligosaccharides contain N-acetylneuraminic acid. The neutral oligosaccharides obtained from all acidic oligosaccharides by sialidase digestion are identical. By the combination of sequential exoglycosidase digestion and methylation analysis, the structures of the asparagine-linked sugar chains of human prothrombin were confirmed to be as follows: (sequence in text).
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