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Title: Substituted imidazo[2,3-alpha]pyridine-2-carbamate anthelmintics. Author: Bochis RJ, Olen LE, Waksmunski FS, Mrozik H, Eskola P, Kulsa P, Wilks G, Taylor JE, Egerton JR, Ostlind DA, Olson G. Journal: J Med Chem; 1981 Dec; 24(12):1518-21. PubMed ID: 7310830. Abstract: Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2-alpha]pyridine-2-carbamate to be the most potent derivative in the series. However, evaluation in sheep indicated that its anthelmintic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2-alpha]pyridine-2-carbamate.[Abstract] [Full Text] [Related] [New Search]