These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: Substituted imidazo[2,3-alpha]pyridine-2-carbamate anthelmintics.
    Author: Bochis RJ, Olen LE, Waksmunski FS, Mrozik H, Eskola P, Kulsa P, Wilks G, Taylor JE, Egerton JR, Ostlind DA, Olson G.
    Journal: J Med Chem; 1981 Dec; 24(12):1518-21. PubMed ID: 7310830.
    Abstract:
    Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2-alpha]pyridine-2-carbamate to be the most potent derivative in the series. However, evaluation in sheep indicated that its anthelmintic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2-alpha]pyridine-2-carbamate.
    [Abstract] [Full Text] [Related] [New Search]