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  • Title: Interaction of aromatic dyes with the coenzyme A binding site of choline acetyltransferase.
    Author: Mautner HG, Merrill RE, Currier SF, Harvey G.
    Journal: J Med Chem; 1981 Dec; 24(12):1534-7. PubMed ID: 7310833.
    Abstract:
    The interaction of a series of aromatic dyes with the coenzyme A binding site of choline acetyltransferase was studied. Several of the dyes were very potent inhibitors of the enzyme. With few exceptions, inhibition was competitive with respect to acetylcoenzyme A and noncompetitive with respect to choline. It appears likely that inhibition by dyes such as Reactive Blue 2 (Cibacron Blue F3GA) or Congo Red, as in the case of coenzyme A interactions, involves hydrophobic bonding, as well as a coulombic interaction with an arginine residue.
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