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  • Title: The effect of RES blockade on red blood cell survival.
    Author: Uchida T, Matsuda S, Tanaka T, Sato T, Yui T, Kokubun R, Kumano M, Kariyone S.
    Journal: Tohoku J Exp Med; 1981 Nov; 135(3):247-53. PubMed ID: 7314112.
    Abstract:
    The effect of RES blockade on the survival of heat-damaged and antibody coated red blood cells was evaluated in C3H mice. RES function of C3H mice was determined by the survival of 59Fe-labeled, heat-damaged red blood cells at 49 degrees C for 30 min. When animals were treated with an intravenous injection of non-labeled, heat-damaged red blood cells for the blockade of RES, red blood cell destruction was depressed in non-splenectomized and splenectomized mice. In the survival or organ distribution of 59Fe-labeled, antibody-coated red blood cells, no difference was noted between animals with and without blockade. These findings suggest that heat-damaged red blood cells were destructed predominantly in the splenic RES and antibody coated cells were not broken down only by the splenic RES.
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