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  • Title: D-penicillamine and the ocular myasthenic syndrome.
    Author: Kimbrough RL, Mewis L, Stewart RH.
    Journal: Ann Ophthalmol; 1981 Oct; 13(10):1171-2. PubMed ID: 7316342.
    Abstract:
    D-penicillamine is a potent drug used to treat rheumatoid arthritis, Wilson's disease and cystinuria. D-penicillamine has recently been found to cause myasthenia gravis in certain susceptible patients. We present a typical case of one patient who developed myasthenia while taking D-penicillamine. The withdrawal of D-penicillamine and the institution of short-term anticholinesterase therapy resulted in the resolution of this disease. The literature is reviewed and attention is focused on the point that all patients who developed myasthenia while undergoing D-penicillamine therapy had ocular symptoms.
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