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  • Title: DNA double-strand breaks and alkali-labile bonds produced by bleomycin.
    Author: Povirk LF, Wübter W, Köhnlein W, Hutchinson F.
    Journal: Nucleic Acids Res; 1977 Oct; 4(10):3573-80. PubMed ID: 73164.
    Abstract:
    Both in linear T2 DNA, analyyzed by velocity sedimentation, and in supercoiled Col EL DNA, analyzed by gel electrophoresis, the number of double-strand breaks produced by bleomycin was directly propotional to the number of single-strand breaks and was far greater than the number expected from random coincidence of single-strand breaks, suggesting that the bleomycin-induced double-strand breaks occur as an independent event. In Col EL DNA, at least twice as many single-strand breaks were found under alkaline assay conditions as were found under neutral conditions, showing the production of alkaline-labile bonds by bleomycin.
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