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  • Title: Chromosome breakage and sister chromatid exchange frequencies in scleroderma.
    Author: Sherer GK, Jackson BB, Leroy EC.
    Journal: Arthritis Rheum; 1981 Nov; 24(11):1409-13. PubMed ID: 7317118.
    Abstract:
    Peripheral lymphocytes from 3 scleroderma patients with systemic disease and from 3 normal controls were examined for frequencies of chromosomal aberration and sister chromatid exchange (SCE). Significant increases in the levels of chromosomal anomaly and SCE were found for all 3 patients. These results are discussed in terms of the diagnostic potential of SCE in scleroderma and the possible etiologic role of cytogenetic instability in this disease.
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