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  • Title: [Role of protonophore activity of oxalacetic acid in inducing Ca2+ yield from mitochondria].
    Author: Gagel'gans AI, Asrarov MI, Kazakov I, Shkinev AV, Mirkhodzhaev UZ.
    Journal: Biofizika; 1981; 26(6):1004-10. PubMed ID: 7317485.
    Abstract:
    It has been found earlier in Lehninger's Laboratory [24] that oxidation of endogenous PN mitochondria induced by oxalacetic acid (OAA) brings about the release of accumulated Ca2+. Analysis of possible mechanism of this phenomenon has shown that OAA has protonophore activity on mitochondria and BPM unlike the malate--the product of enzymic reduction of OAA in the presence of NAD . H. OAA-induced permeability of BPM and mitochondria membranes for H+ is observed at pH 7.5-8.0 and is insignificant at pH 7.0 and lower. Possible function of OAA as a soft uncoupler-protonophore controlled by metabolism is discussed, in particular--in connection with Ca2+ transport in mitochondria.
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