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  • Title: Red-cell metabolism of pyridoxine in controls and beta-Thalassaemia in Ferrara, Northern Italy.
    Author: Anderson BB, Perry GM, Clements JE, Vullo C, Cristofori G.
    Journal: Biomedicine; 1981 Oct; 35(5):147-50. PubMed ID: 7317562.
    Abstract:
    The rate of red-cell metabolism of pyridoxine to pyridoxal phosphate was measured in control subjects and patients with homozygous and heterozygous beta-thalassaemia from Ferrara, Northern Italy, and in British control subjects of Anglo-Saxon origin. A high incidence of a slow rate of B6 metabolism was found in beta-thalassaemia in Ferrara similar to that found previously in Cypriots living in London. Of particular interest was a much slower rate in control subjects from Ferrara than in British control subjects of Anglo-Saxon origin. The suggestion that a high incidence of a slow red-cell metabolism of B6 is the result of selection by malaria, whether associated with thalassaemia or not, is considered.
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