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  • Title: [Changes in the ploidies of hepatocyte nuclei of animals with transplantable tumors during liver regeneration and x-irradiation].
    Author: Sizikov AI.
    Journal: Biull Eksp Biol Med; 1981 Oct; 91(10):473-6. PubMed ID: 7317611.
    Abstract:
    Alterations in ploidy of hepatocyte nuclei were followed in experiments on 190 rats with transplantable tumors during liver regeneration and x-ray irradiation. The presence of the growing transplantable tumor in the animal's body led to alterations in the nuclear structure of hepatocytes, manifesting in the increased ploidy. X-Ray irradiation brought about a rise in hepatocyte ploidy which was more remarkable the higher the dose. Under such conditions, polyploidy of hepatocyte nuclei was more pronounced in tumor-bearing rats than in those without tumors. An abrupt increase in ploidy of hepatocyte nuclei occurred in the regenerating liver of tumor-bearing animals both non-irradiated and, particularly, irradiated ones.
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