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Title: In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands. Author: Ben-Barak J, Gazit H, Silman I, Dudai Y. Journal: Eur J Pharmacol; 1981 Aug 27; 74(1):73-81. PubMed ID: 7318895. Abstract: Administration of the muscarinic agonist oxotremorine led to a decrease in the number of muscarinic receptors, as determined by specific binding of [3H]quinuclidinyl benzilate ([3H]QNB), in several rat brain regions both during development and at maturity. In contrast, administration of the muscarinic antagonist scopolamine led to an increase in the number of [3H]QNB-binding sites in various brain regions. Scopolamine also prevented the decrease in the number of [3H]QNB-binding sites induced by administration of an organophosphorus drug. The results are compatible with the hypothesis that the number of brain muscarinic receptors, or at least of a sub-class of them, is regulated by their transmitter.[Abstract] [Full Text] [Related] [New Search]