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  • Title: Evaluation of amphetamine-induced in vivo electrochemical response.
    Author: Dayton MA, Ewing AG, Wightman RM.
    Journal: Eur J Pharmacol; 1981 Oct 22; 75(2-3):141-4. PubMed ID: 7318902.
    Abstract:
    A carbon fiber microelectrode is shown to give a potential-dependent dopamine-selective response in rat brain tissue. However, distinct evidence for dopamine release is not obtained with intraperitoneal amphetamine administration (1.8 or 3.7 mg . kg-1). In rats which have been unilaterally depleted of dopamine, the change in electrochemical signal obtained in the lesioned striatum is very similar to that measured on the non-lesioned side following amphetamine administration. This indicates that substances other than dopamine contribute to the observed signals.
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