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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Des-tyrosine1-gamma-endorphin increases the antinociceptive efficacy of morphine in the rat.
    Author: Neil A, Lahti RA, Lindeberg G, Terenius L.
    Journal: Eur J Pharmacol; 1981 Nov 19; 76(1):93-5. PubMed ID: 7318926.
    Abstract:
    Repeated injections of des-tyrosine1-gamma-endorphin (DT gamma E) to rats subjectively increased sensitivity to handling. After 8 days of treatment, the animals were supersensitive to a low dose of morphine in the foot-shock test. Acute treatment with DT gamma E gave no significant increase in morphine sensitivity. The results indicate that DTgammaE given chronically interacts with opioid receptor-effector mechanisms.
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