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  • Title: Difference between magnesium and manganese ions in modification of effect of catecholamine on adenylate cyclase system in Ehrlich ascites tumor cells.
    Author: Kurokawa T, Kitamura Y, Moriuchi M, Ishibashi S.
    Journal: J Pharmacobiodyn; 1981 Oct; 4(10):794-7. PubMed ID: 7320831.
    Abstract:
    Involvement of divalent cations was examined in the activation of catecholamine sensitive adenylate cyclase in Ehrlich ascites tumor cells. In the presence of various concentrations of either Mg2+ or Mn2+, both basal and norepinephrine-stimulated, adenylate cyclase activities were measured. Both activities were gradually increased with the increase in Mg2+ concentration. On the other hand, with Mn2+, both activities were maximum at the low (2.5 mM) concentration, and decreased at the highest concentrations, the decrease being marked in the norepinephrine-stimulated activity. Similar difference between the two divalent cations was also observed in the effect on the binding of the beta-adrenergic ligand to the membrane receptor.
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