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  • Title: Unscheduled synthesis of DNA and poly(ADP-ribose) in human fibroblasts following DNA damage.
    Author: McCurry LS, Jacobson MK.
    Journal: J Supramol Struct Cell Biochem; 1981; 17(1):87-90. PubMed ID: 7321056.
    Abstract:
    Unscheduled DNA synthesis has been measured in human fibroblasts under conditions of reduced rates of conversion of NAD to poly)ADP-ribose). Cells heterozygous for the xeroderma pigmentosum genotype showed normal rates of UV induced unscheduled DNA synthesis under conditions in which the rate of poly(ADP-ribose) synthesis was one-half the rate of normal cells. The addition of theophylline, a potent inhibitor of poly(ADP-ribose) polymerase, to the culture medium of normal cells blocked over 90% of the conversion of NAD to poly(ADP-ribose) following treatment with UV or N-methyl-N'-nitro-N-nitro-soguanidine but did not affect the rate of unscheduled DNA synthesis.
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