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  • Title: [Action of piribedil on synaptic transmission in the cockroach central nervous system (Periplaneta americana L.) (author's transl)].
    Author: Hue B, Pelhate M, Chanelet J.
    Journal: J Pharmacol; 1981; 12(4):455-63. PubMed ID: 7321574.
    Abstract:
    1. Experiments were performed on the sixth abdominal ganglion of the cockroach, Periplaneta americana. Excitatory postsynaptic potentials (EPSPs) were recorded using the single-fibre oil-gap technique and mannitol-gap technique. 2. Piribedil (10(-5) to 10(-3) M) which did not alter neurons conduction in pre- and postsynaptic fibers, depressed unitary EPSPs as well as evoked EPSPs. 3. The acetylcholine depolarizing response was consistently reduced in ganglia pretreated with piribedil. 4. It is suggested that piribedil acts on cholinergic postsynaptic receptors as an antagonist.
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