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  • Title: [Erythrocyte levels of ALA-dehydrase and uro-synthetase in chronic renal insufficiency (author's transl)].
    Author: Tabernero Romo JM, Pérez Sandoval D, Rodríguez Commes JL, Rico Sánchez J, Macías Núñez JF, Corbacho Becerra L, Juanes A, de Castro S.
    Journal: Med Clin (Barc); 1981 Jun 25; 77(2):69-71. PubMed ID: 7321629.
    Abstract:
    Erythrocyte levels of ala-dehydrase and uro-synthetase as well as hematocrit, hemoglobin, iron levels and serum iron binding capacity were studied in a group of 28 patients with chronic renal failure in hemodialysis and compared to those of a control group. As is usual, hematocrit, hemoglobin an iron levels were significantly decreased, as were ala-dehydrase levels, while uro-synthetase levels were within normal levels. These results are interpreted as a blockade of the biosynthetic pathway of the protoporphyrins, which lends support to the hypothesis of an existing defect in hemoglobin synthesis in patients with chronic renal failure.
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