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  • Title: [Analysis of structural divergence of H1N1 serotype influenza virus individual genes].
    Author: Shilov AA, Kozlov IuV, Kurmanova AG, Gorbulev VG, Selivanov IaM.
    Journal: Mol Biol (Mosk); 1981; 15(6):1371-84. PubMed ID: 7322123.
    Abstract:
    A comparative structural analysis of H1N1 influenza virus isolated in 1977 (the A/USSR/90/77 strain) and H1N1 isolates of 1947 (the A/FM/1/47 strain) and 1950 (the A/FW/1/50 strain) have been carried out by oligonucleotide mapping of individual viral RNA segments. Seven of eight genes of A/USSR/90/77 strain have a high degree of homology with corresponding genes of A/FW/1/50 strain, especially the genes coding the NP and P2 proteins. At the same time the gene coding matrix (M) protein has higher structural similarity to the corresponding gene of A/FM/1/47 strain. Based on the results presented one may conclude that the A/USSR/90/77 epidemic strain is a recombinant virus.
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