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  • Title: Effect of capsaicin on the intraperitoneal axons of the rat trachea.
    Author: Hoyes AD, Barber P, Jagessar H.
    Journal: Neurosci Lett; 1981 Nov 04; 26(3):329-34. PubMed ID: 7322444.
    Abstract:
    In vitro exposure of specimens of rat trachea to capsaicin at a concentration of 2 x 10(-4) g/ml was followed by a significant increase in the diameter and major changes in the vesicle content of intraepithelial axons with terminals containing a high proportion of large dense-cored vesicles and only scattered small vesicles, but had no effect on axons with terminals containing large numbers of closely-packed small vesicles. Twenty-four hours after in vivo treatment of rats with capsaicin at dose levels of 50 mg/kg, there was a highly significant reduction in the number of axons/unit length in the tracheal epithelium. This was attributed to similar patterns of degeneration of axons with terminals containing a high proportion of large dense-cored vesicles to those seen in the ureter and to the early elimination of the degenerating axons by phagocytosis by the epithelial cells.
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