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  • Title: Drug-polymer combinations. Part 1: The preparation of sustained release drugs by combination with ion exchanging resins.
    Author: Gyselinck P, van Severen R, Braeckman P, Schacht E.
    Journal: Pharmazie; 1981 Nov; 36(11):769-72. PubMed ID: 7323125.
    Abstract:
    The preparation of procainamide and propranolol resinates is described. By in vivo experiments with propranolol resinate as model substance the release rate as a function of crosslinking degree and particle size is studied. An in vitro test is carried out to compare the performance as prolonged release preparation of a resinate, e.g. procainamide resinate, with the action of the pure drug and of a Durette formulation.
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