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  • Title: Serum levels and clearance of bile acids are unaffected by jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio.
    Author: Sørensen TI, Bruusgaard A, Nyboe Andersen A, Andersen B.
    Journal: Scand J Gastroenterol; 1981; 16(6):705-11. PubMed ID: 7323704.
    Abstract:
    Jejunoileal bypass may impair liver function. The hypothesis of the present study was that this may depend on the jejunoileal ratio of the segment left in continuity in a manner that affects the transport of bile acids from blood to bile. We investigated five extremely obese patients before and 29 patients 3, 9 and 15 months after bypass surgery with a 3:1 or 1:3 jejunoileal ratio of the functioning segment. Routine liver function tests, plasma disappearance rate of intravenously administered 3H-cholic acid and 14C-24-chenodeoxycholic acid, and fasting and postprandial serum concentrations of total 3-alpha-hydroxy bile acids showed no appreciable significant relationship with bypass surgery as such, time after surgery, or the jejunoileal ratio of the functioning segment.
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