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  • Title: A critical analysis of the gastric secretory response of patients with duodenal ulcer in dependence of their age and duration of complaints.
    Author: Mózsik G, Venter E, Schmelczer M, Kutas J, Nagy L, Tárnok F.
    Journal: Acta Med Acad Sci Hung; 1981; 38(2):117-28. PubMed ID: 7324803.
    Abstract:
    The different parameters of the basal and maximal gastric secretory responses were measured in 120 patients with duodenal ulcer. The correlations between the different gastric secretory parameters [volume, H+ concentration, basal acid output (BAO), maximal acid output (MAO), maximal acid output-basal acid output, basal acid output . maximal acid output X 100] were studied in these patients, in dependence of their age and duration of complaints. A positive and mathematically significant correlation was found between the following parameters: 1. age of patients and H+ concentration of gastric basal secretion (r = 0.326; n = 120; P less than 0.001); 2. age of patients and basal acid output (r = 0.200; P less than 0.05); 3. duration of complaints and volume of gastric basal secretion (r = 0.186; P less than 0.05); 4. duration of complaints and basal acid output (r = 0.237; P less than 0.05); 5. age of patients and BAO . MAO-1 X 100 (r = 0.216; P less than 0.05); 6. duration of complaints and BAO. MAO-1 X 100 (4 = 0.197; P less than 0.05); 7. volume of gastric maximal and basal secretory response (r = 0.398; P less than 0.001); 8. H+ concentration of gastric maximal and basal secretory response (r = 0.480; P less than 0.001); 9. MAO and BAO values (r = 0.521; P less than 0.001); 10. H+ output and H+ concentration of gastric basal secretory response (r = 0.620; P less than 0.001); 11. H+ output and volume of gastric basal secretory response (r = 0.779; P less than 0.001); 12. H+ concentration and volume of gastric maximal secretory response (r = 0.298; P less than 0.01); 13. H+ output and H+ concentration of gastric maximal secretory response (r = 0.720; P less than 0.001); 14. H+ output and volume of gastric maximal secretory response (r = 0.802; P less than 0.001). A negative and mathematically significant correlation was observed between the values of BAO . MAO-1 X 100 and of MAO - BAO (r = 0.435; P less than 0.001). It has been concluded 1. duodenal ulcer disease protects the human gastric fundic mucosa against "senile decay"; 2. the changes of gastric basal and maximal secretory responses, induced by duodenal ulcer, do not supply a pathological base for gastric surgery in patients, on dependence on their ages and duration of complaints.
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