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  • Title: Sister chromatid exchanges in lymphocytes after anaesthesia with halothane or enflurane.
    Author: Husum B, Wulf HC, Niebuhr E.
    Journal: Acta Anaesthesiol Scand; 1981 Apr; 25(2):97-8. PubMed ID: 7324832.
    Abstract:
    The potential mutagenicity of inhalation anaesthetics was investigated by the sister chromatid exchange (SCE) test system applied to lymphocytes in peripheral blood drawn from patients before and after anaesthesia. Twenty-one women, aged 39-82 years (median 57.7 years) received halothane for 75-180 min (median 125 min). Fourteen other patients, aged 45-90 years (median 67.5 years) received enflurane for 90-180 min (median 130 min). In both groups the numbers of SCEs were unchanged immediately following anaesthesia and 5 days after. It was concluded that, by this method, comprising human cells exposed in vivo, there was no indication of mutagenic effect of short-term exposure to halothane or enflurane in anaesthetic concentrations.
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