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  • Title: Pharmacokinetics of gentamicin in the juvenile dog.
    Author: Riviere JE, Coppoc GL.
    Journal: Am J Vet Res; 1981 Sep; 42(9):1621-3. PubMed ID: 7325472.
    Abstract:
    The pharmacokinetics of gentamicin and/or creatinine clearances were investigated in eleven 5-month-old Beagles. A 2-compartment open model was used to describe the drug's disposition, as judged by error sums of squares and residual plot analyses. Half-life (elimination phase) was 60.9 +/- 7.8 minutes (mean +/- SD), the volume of distribution calculated from the area under the curve was 35.4 +/- 3.6 L/100 kg of body weight, and the clearance of the drug from the body was 4.08 +/- 0.62 ml/min/kg of body weight. The 24-hour creatinine renal clearance in these dogs was 3.82 +/- 0.92 ml/min/kg, consistent with gentamicin being eliminated mainly by glomerular filtration. Other pharmacokinetic values were also determined.
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