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  • Title: [Sulfadimethoxine pharmacokinetics in chronic nephritis with nephrotic syndrome].
    Author: Bobrov VI, Segel'man VS, Iakovlev VP.
    Journal: Antibiotiki; 1981 Dec; 26(12):936-8. PubMed ID: 7325625.
    Abstract:
    Sulfadimethoxine excreted more rapidly in patients with chronic nephritis and the nephrotic syndrome than in subjects of the control group. Increased elimination of sulfadimethoxine from the blood of the persons with the kidney diseases was due to decreased reabsorption of the drug in the kidney tubules and increased rates of the drug biotransformation because of decreased binding by the blood serum proteins.
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