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  • Title: Biliary excretion of diazepam in rats: influence of the route of administration and dosage.
    Author: Phillips R, Plaa GL.
    Journal: Arch Int Pharmacodyn Ther; 1981; 253(2):180-91. PubMed ID: 7325758.
    Abstract:
    The biliary excretion of diazepam metabolites was found in rats. Equivalent dosages of diazepam were administered orally and intraperitoneally. The biliary excretion was dose-dependent and was greater following intraperitoneal administration. After intravenous administration, a greater percentage of the diazepam dosage administered was excreted into the bile. Repetitive intravenous administrations yielded results which approached those observed after intraperitoneally administered dosages given as a bolus.
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