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  • Title: Isolation and identification of mercapturic acids of cinnamic aldehyde and cinnamyl alcohol from urine of female rats.
    Author: Delbressine LP, Klippert PJ, Reuvers JT, Seuttler-Berlage F.
    Journal: Arch Toxicol; 1981 Nov; 49(1):57-64. PubMed ID: 7325801.
    Abstract:
    Rats dosed with cinnamic aldehyde (I) excreted two mercapturic acids in the urine. The major one was identified as N-acetyl-S-(1-phenyl-3-hydroxypropyl)cysteine (V). The minor one was identified as N-acetyl-S-(1-phenyl-2-carboxy ethyl)cysteine (VI). The ratio appeared to be V : VI = 4 : 1. The hydroxy mercapturic acid (V) was also isolated from urine of rats dosed with cinnamyl alcohol (II). The total mercapturic acid excretion as percentage of the dose was 14.8 +/- 1.9% for cinnamic aldehyde (250 mg/kg) (n = 4) and 8.8 +/- 1.7% for cinnamyl alcohol (n = 4) (125 mg/kg). Inhibition of the alcohol dehydrogenase by pyrazole (206 mg/kg) diminished the thioether excretion of cinnamyl alcohol to 3.3 +/- 1.4% of the dose (n = 8). Cinnamic aldehyde has been proposed to be an intermediate in the mercapturic acid formation of cinnamyl alcohol.
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