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  • Title: Evidence against the reported antithiamine effect of caffeic and chlorogenic acids.
    Author: Horman I, Brambilla E, Stalder R.
    Journal: Int J Vitam Nutr Res; 1981; 51(4):385-90. PubMed ID: 7327861.
    Abstract:
    Contrary to earlier literature reports, chlorogenic acid (I) is shown to have little or no deleterious effect on thiamine (II) when the 2 compounds are codissolved in aqueous solution. Evidence from nmr spectroscopy and from t. l. c. determination demonstrate that when II is heated at 60 degrees C and at pH 7.8 for 24h, about 10% is destroyed. This result is the same whether I is present or not. Incubating II with I or with caffeic acid (III) in a phosphate buffer at pH 7 or in thiamine assay medium at pH 6 for up to 24h at 37 degrees C did not reduce the growth activity of II or Lactobacillus viridescens. We conclude that I and III are not antithiamine agents.
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