These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Syntheses of 9-substituted josamycin, 13-substituted isojosamycin and their tetrahydro derivatives.
    Author: Tanaka A, Watanabe A, Kobayashi R, Tsuchiya T, Umezawa S, Hamada M, Umezawa H.
    Journal: J Antibiot (Tokyo); 1981 Sep; 34(9):1137-51. PubMed ID: 7328055.
    Abstract:
    Derivatives of josamycin and isojosamycin modified at C-9 and C-13 have been prepared by reaction sequences involving treatment of josamycin with alcohols, phenol or 1-methyl-1H-tetrazol-5-ylthiol in acidic media. Several tetrahydro derivatives of josamycin and isojosamycin have also been prepared by reaction sequences involving catalytic hydrogenation. From the 1H NMR studies, it was found that the conformation of the macro-lactone portion of 13-O-methylisojosamycin dimethylacetal, a key intermediate, is flexible and changeable with variation of the solvent.
    [Abstract] [Full Text] [Related] [New Search]