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  • Title: Possible inhibitory influence of gamma-aminobutyric acid on growth hormone secretion in the rat.
    Author: Fiók J, Acs Z, Stark E.
    Journal: J Endocrinol; 1981 Dec; 91(3):391-7. PubMed ID: 7328370.
    Abstract:
    Increasing the levels of endogenous gamma-aminobutyric acid (GABA) by treating rats with GABA-transaminase inhibitors (ethanolamine-O-sulphate and gamma acetylenic GABA) resulted in a decrease in plasma levels of GH. Diminishing GABAergic activity by inhibiting GABA synthesis with 3-mercaptopropionic acid or by blocking GABA receptors with bicuculline increased plasma concentration of GH. The presence of GABA was without effect on the basal, somatostatin-inhibited or high K+-stimulated secretion of GH by hemipituitary glands in vitro. The results suggest that GABA inhibits secretion of GH under the given experimental circumstances.
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