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  • Title: A double-blind comparison of high and low doses of levamisole in rheumatoid arthritis.
    Author: Pinals RS, Robertson F, Blechman WJ.
    Journal: J Rheumatol; 1981; 8(6):949-51. PubMed ID: 7328569.
    Abstract:
    A randomized, double-blind study was performed to compare the efficacy of 2 different regimens for levamisole in the treatment of rheumatoid arthritis over a period of six months. A dose of 150 mg once weekly was shown to be less efficacious than 150 mg on 3 consecutive days. Although the low dose produced fewer adverse effects, only subjective improvement was demonstrated. Only 14% of patients responded to the low dose, according to defined criteria, compared with 45% response to the high dose.
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