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  • Title: N*-N*-S* tridentate ligand system as potential antitumor agents.
    Author: Antonini I, Claudi F, Cristalli G, Franchetti P, Grifantini M, Martelli S.
    Journal: J Med Chem; 1981 Oct; 24(10):1181-4. PubMed ID: 7328579.
    Abstract:
    Compounds containing an N*-N*-S* tridentate ligand were synthesized and tested for antitumor activity against P-388 lymphocytic leukemia in mice. Of these, only 2,2'-bipyridyl-6-carbothioamide (1a) showed antitumor activity at relatively high dosage levels. Compound 1a was also evaluated against L-1210 and S180 cells in culture and found to have significant activity.
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