These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Hypotensive effects of practolol and atenolol after blood-brain barrier lesion in normotensive and hypertensive rats].
    Author: Davy M, Lindenbaum A, Cohen Y, Wepierre J.
    Journal: Paroi Arterielle; 1980; 6(4):219-24. PubMed ID: 7329713.
    Abstract:
    Practolol (15 mg/kg i.c.) and atenolol (3 mg/kg i.v.) induced in rats hypotensive effects different from one group to another. However these hypotensive effects were always more important in hypertensive than in normotensive animals. IN Okamoto rats, hypotensive effect of atenolol increased with the age of the animals. In normotensive rats, atenolol had no effect whatever the animal age. Evans blue injected by intracarotid route in normotensive and hypertensive rats showed an increased permeability in Okamoto rats blood-brain barrier. After lesion of blood-brain barrier by intracarotid injected cetrimonium, hypotensive effect of the two beta-blocking drugs appeared in both normotensive and hypertensive rats, with a greater degree than in control rats.
    [Abstract] [Full Text] [Related] [New Search]