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  • Title: A chemically unmasked, chloride dependent K+ transport in low K+ sheep red cells: genetic and evolutionary aspects.
    Author: Lauf PK.
    Journal: Prog Clin Biol Res; 1981; 56():13-34. PubMed ID: 7330007.
    Abstract:
    Recent evidence for a chemically unmasked, Cl- dependent K+ transport system present in LK sheep red cells has been reviewed. Exposure of LK cells to millimolar concentrations of N-ethylmaleimide (NEM) caused an up to 10 fold increase of a Cl- dependent K+ permeability with saturation kinetics and a low K+ affinity. Genetically associated with the expression of the LK gene, the chemically uncovered, Cl- activated K+ flux resembles evolutionary ancient cation transport systems found in nucleated red cells and non-erythrocytic mammalian cells. Perhaps the K+ transport system here described may play a significant role in volume reduction when sheep reticulocytes "mature" to adult red cells.
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