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  • Title: Investigation of alveolar macrophage function using lucigenin-dependent chemiluminescence.
    Author: Williams AJ, Cole PJ.
    Journal: Thorax; 1981 Nov; 36(11):866-9. PubMed ID: 7330811.
    Abstract:
    The method using lucigenin-dependent phagocytic chemiluminescence is described for the assessment of alveolar macrophage metabolic activity in response to stimulation by opsonised particles or soluble agents. The requirement for superoxide anion (O2-) in the production of chemiluminescence is suggested by inhibition (95%) using superoxide dismutase. The results obtained are correlated with those obtained using another method of detecting O2- release (r = 0.61; p less than 0.05) and are also related by regression analysis to polymorphonuclear leucocyte contamination of the alveolar macrophage suspension. This shows that alveolar macrophages produce lucigenin-dependent chemiluminescence of the same order of magnitude as do polymorphonuclear leucocytes.
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