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  • Title: Participation of inorganic phosphate in the chemiosmotic mechanism of mitochondrial energy transduction.
    Author: Fonyó A, Lukács G, Ligeti E.
    Journal: Acta Biol Med Ger; 1981; 40(7-8):907-14. PubMed ID: 7331635.
    Abstract:
    In respiring liver mitochondria in which Pi transport was inhibited and the intramitochondrial Pi value manipulated to vary about 3-fold, K+-ion uptake, H+-ion extrusion and stimulation of respiration were linearly related to the intramitochondrial Pi content. It is suggested that the HPO 2(4)-anion generated during respiration is the nondiffusible anion required for the Donnan distribution and membrane potential in mitochondria. The intramitochondrial H X HPO4-ionic species is the proton donor required for coupled respiration. The electroneural Pi-H+ cotransport closes the proton cycling in respiration.
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