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  • Title: To the management of the solitary thyroid nodule.
    Author: Haugen SE, Sørlie DG, Saebøe-Larssen J, Sundsfjord JA.
    Journal: Acta Chir Scand; 1981; 147(3):193-5. PubMed ID: 7331656.
    Abstract:
    Excisional biopsy with peroperative frozen section and later paraffin section examination was performed in 107 consecutive cases of solitary thyroid nodules. Frozen section gave a correct diagnosis in 99 cases (92%). A false benign diagnosis was made in 6 cases, one was inconclusive and one was false malignant (Hürthle cell tumor). Technetium scintigraphy was of no definite diagnostic value. Malignancy was found in 25 cases (23%) in which the whole gland was removed. Multicentric bilateral lobe involvement was encountered in 7 patients. Lack of reliable preoperative diagnostic methods makes liberal excisional biopsy of all solitary thyroid nodules advisable.
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