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  • Title: [A doubleblind comparison of tramadol and buprenorphine in the control of postoperative pain (author's transl)].
    Author: Alon E, Schulthess G, Axhausen C, Hossli G.
    Journal: Anaesthesist; 1981 Dec; 30(12):623-6. PubMed ID: 7332090.
    Abstract:
    Analgesic effects as well as side effects, circulatory and respiratory parameters of 50 mg tramadol (Tramal) were compared with 0.3 mg buprenorphine (Temgesic) in a doubleblind, randomized study for the relief of postoperative pain. Buprenorphine produced a more potent and longer acting analgesic effect compared to tramadol, although slightly delayed. There were only few and slight side effects and no influence on the circulation and respiration. In the search for a new long-acting and strong analgesic Tramadol proved to be unable to replace buprenorphine in the control of postoperative pain.
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