These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Uterine activity and blood flow in response to sulprostone during midtrimester pregnancy termination.
    Author: Pulkkinen MO.
    Journal: Arch Gynecol; 1981; 231(1):57-9. PubMed ID: 7332359.
    Abstract:
    Sulprostone in a new prostaglandin E2 (PGE2) derivative (16-phenoxy methylsulfonyl-amide PGE2) can be used for pregnancy termination and can also be used to avoid hysterectomy in cases of heavy bleeding due to uterine atony. This study examines the effects of intravenous sulprostone on uterine blood flow by studying the color of the uterus during hysterotomy in the 2nd trimester. 12 multiparous patients in the 2nd trimester of pregnancy (age 36 +or- 2 years old, gravida 5 +or- 0.6, para 3 +or- 0.4) underwent hysterotomy and tubal ligation. A color photograph of the uterus was taken and a sulprostone drip (5 mcg/minute in isotonic saline) was started in 9 patients, the other 3 serving as controls. During the tubal ligation surgery, more pictures were taken at 3, 5, 10, 15, and 20 minutes. A fixed microballoon method recorded intrauterine pressure while a Gretag D 23 densitometry analyzed color intensity at 5 points of the photographs. The average of 5 readings was used for further analyses. A significant change in the blue color was observed (p 0.05). 3 independent outsiders who had no knowledge of the times the pictures were taken were able to distinguish the pictures which had been taken after 15-20 minutes of sulprostone exposure. Uterine contractile response to sulprostone was close to the maximum after 15-20 minutes of infusion. A slight increase of cyclic uterine activity was observed, as was a very pronounced increase in resting pressure. This study shows that intravenous sulprostone infusion resulted in a uterine contracture response and a change in the color of the uterine surface. It justifies the use of sulprostone for severe postpartum hemorrhage.
    [Abstract] [Full Text] [Related] [New Search]